TTP

[fataunt]

TTP ...Titan Pharmaceuticals...rumor for take over by its partner AG schenig..and very good looking chart ( sorry I dont know how to copy chart here)..but do your own DD...looking
very good company...ready to break 5 IMO

[setravis]

Pre-market monster......


TITAN PHARMA INC (AMEX:TTP) Delayed quote data 

Pre-Market: @ $3.88  +$1.51 (+63.71%)

[setravis]

Now here is the early morning chart......

[kslifka]

Anyone know why TTP is up so much.

[setravis]

Press Release Source: Titan Pharmaceuticals, Inc.


Titan Reports Positive Results in Iloperidone Phase III Clinical Trial
Thursday December 7, 1:46 pm ET


SOUTH SAN FRANCISCO, Calif.--(BUSINESS WIRE)--Titan Pharmaceuticals, Inc. (AMEX:TTP - News) today announced positive results from a Phase III clinical trial evaluating iloperidone, an atypical antipsychotic, in patients with schizophrenia. In this important study, iloperidone demonstrated statistically significant improvement compared to placebo on the Positive and Negative Symptom Scale (PANSS), the trial's primary endpoint. Iloperidone also achieved significant efficacy on the positive and negative symptom subscales of PANSS. The safety profile was consistent with what has been observed in previous iloperidone Phase III trials.


Iloperidone's efficacy and safety was also evaluated in this study in patients with specific genetic profiles using pharmacogenetics (PG), in order to potentially give physicians and patients information to help individualize their antipsychotic therapy. It had been previously identified that a certain polymorphism in a gene, occurring in approximately 70% of patients, may be associated with the pathogenesis of schizophrenia and appeared to correlate with iloperidone response. Iloperidone achieved statistical significance vs. placebo on the PANSS scale in these patients, with a magnitude of response greater than that seen in the overall iloperidone population.

The Phase III trial was a randomized, double-blind, placebo-controlled, multi-center, 4 week study that enrolled 604 patients with schizophrenia. The trial evaluated 12 mg of iloperidone dosed twice-daily, or 24 mg per day. The primary endpoint was efficacy vs. placebo in PANSS (total) using the Mixed Method Repeated Measures (MMRM) methodology. The secondary endpoint was efficacy in the previous described genetic subpopulation.

The efficacy results vs. placebo include:

* Efficacy (intent to treat population):

* PANSS (total): p=0.006

* PANSS (positive symptoms only): p=0.0009

* PANSS (negative symptoms only): p=0.027

* Brief Psychiatric Rating Scale (BPRS): p=0.0128

* Efficacy (genetic subpopulation):

* PANSS (total): p=0.002

Using Last Observation Carried Forward (LOCF) methodology, iloperidone achieved statistical significance in both the primary and secondary endpoints. Iloperidone efficacy was also equal to the active control arm.

The study also evaluated the effect of iloperidone on the QT interval, a well understood atypical antipsychotic class side effect. The mean QT prolongation was consistent with previous experience. No patients experienced QT intervals in excess of 500 milliseconds, a threshold of concern to the FDA. The study also confirmed, with an additional genetic marker, that the QT prolongation was shorter in the majority of patients who are good iloperidone metabolizers.

The specific results include:

* QTc change from baseline:

* All patients: 11.4 milliseconds (msec)

* Good metabolizers: 10.4 msec

* Poor metabolizers: 15.0 msec (p=0.008, good vs. poor)

"We are very pleased with these results for iloperidone in this Phase III study", stated Louis R. Bucalo, Chairman, President and CEO of Titan Pharmaceuticals. "These results strongly support our position in the advancement of iloperidone".

The Phase III study was performed by Vanda Pharmaceuticals Inc. (Nasdaq: VNDA - News). Vanda acquired the rights to iloperidone from Titan's sublicensee, Novartis. Vanda plans to file an NDA for iloperidone by the end of 2007. Titan's agreements provide that Titan will receive a royalty of between 8-10% on worldwide sales of iloperidone.

About Schizophrenia

Schizophrenia is a chronic, debilitating mental disorder characterized by hallucinations, delusions, racing thoughts and other psychotic symptoms (collectively referred to as "positive symptoms"), as well as moodiness, anhedonia (inability to feel pleasure), loss of interest, eating and sleep disturbances, and difficulty concentrating (collectively referred to as "negative symptoms"). Schizophrenia develops in late adolescence or early adulthood in approximately 1% of the world's population. Genetic and environmental factors are believed to be responsible for the disease.

About Titan Pharmaceuticals

Titan Pharmaceuticals, Inc. (AMEX:TTP - News) is a biopharmaceutical company focused on the development and commercialization of novel treatments for central nervous system disorders, cardiovascular disease, bone disease and other disorders. Titan's products in development utilize novel technologies that have the potential to significantly improve the treatment of these diseases. Titan also establishes partnerships with government institutions and other leading pharmaceutical development companies. For more information, please visit the Company's website at www.titanpharm.com.

The press release may contain "forward-looking statements" within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934. Such statements include, but are not limited to, any statements relating to the Company's development program and any other statements that are not historical facts. Such statements involve risks and uncertainties, including, but not limited to, those risks and uncertainties relating to difficulties or delays in development, testing, regulatory approval, production and marketing of the Company's drug candidates, unexpected adverse side effects or inadequate therapeutic efficacy of the Company's drug candidates that could slow or prevent product development or commercialization, the uncertainty of patent protection for the Company's intellectual property or trade secrets and the Company's ability to obtain additional financing if necessary. Such statements are based on management's current expectations, but actual results may differ materially due to various factors, including those risks and uncertainties mentioned or referred to in this press release.

Contact:
Titan Pharmaceuticals, Inc.
Robert Farrell
Executive Vice President & CFO
650-244-4990
or
Media/Investors:
The Trout Group
Ian Clements, 415-392-3385

--------------------------------------------------------------------------------
Source: Titan Pharmaceuticals, Inc.

[setravis]

Getting ready for a move.......
Upwards this month and next. It might finally hit that $6 this time for starters, Vanda fully funded now...


52wk Range: 1.55 - 4.99
Volume: 524,700
Avg Vol (3m): 421,685


Technicals
Close Above the 13-day EMA
Percentage Gainer

Last Price Quote is:
3.98%above 13-day MA
13.00%above 50-day MA
RS Rating: 91 

Fundamentals
Key Data:
Market Cap (M): $77.53 
P/E Ratio: NA 
PEG Ratio: N/A 
Next Earnings: N/A
Last Analyst Rating: Mkt Outperform

[ScottishTrader]

On the watchlist for monday.  Looks good.  Cheers for the headsup guys 

[BigSully1]

update

[BigSully1]

Can it break through resistance?

[BigSully1]

VNDA is looking ready to move.  I think fed decision on Iloperidone is due late July. TTP will receive a milestone payment and royalties if approved. I think there is other drug news also pending also this year for TTP, such as Spheramine.